Enhanced C-Terminal Truncation of A- and B- Crystallins in Diabetic Lenses
نویسندگان
چکیده
METHODS. The human lenses were diabetic or age-matched control lenses from donors 57, 59, 69, and 72 years of age. Lenses were also obtained from streptozotocin-induced diabetic rats. Individual lens crystallins in water-soluble fractions were separated by gel-permeation chromatography. The high ( H)and low ( L)-molecular-weight fractions were analyzed by electrospray ionization mass spectrometry.
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